The International Multicentre Pleural Research Collaborative is a collaboration between medical practitioners with an interest in pleural medicine, which provides a platform for pleural disease research that has both global clinical impact and relevance to patients. IMPACT was established as a CRC in 2016, known then as the International Collaborative Effusion Database (ICE db). The collaboration was created by Rahul Bhatagar, Julius Jansen, and Nick Maskell, to bring pleural medicine experts and clinicians together to pool data on rare and neglected pleural diseases.

In the first phase, IMPACT (previously ICE db) created the largest international datasets on non- specific pleuritis, eosinophilic effusions, benign effusions, and chylothorax to date. Under the leadership of the new chairs since 2022, the second phase of IMPACT has an expanded mandate which includes pleural infection, pleural procedures, pleural fluid biomarkers, and other topics selected by the membership. 

In Phase 2 the collaborative will transition from retrospective data collection to prospective
observational studies. This phase will focus on capacity building and setting up pipelines for future
multicentre prospective interventional studies.


IMPACT is led by four Chairs, two Senior and two Early Career members. 

Uffe Bødtger

Consultant in Respiratory Medicine, MD, PhD Clinical professor, Zealand University Hospital, Roskilde & Naestved, Denmark  https://orcid.org/0000-0002-1231-9209

Contact: ubt@regsj.dk
Special interests: endoscopy, thoracic ultrasound, pleural disease, obstructive lung diseases

Federico Mei

Consultant in Respiratory Medicine, MD Clinical Professor, University Hospital, Polytechnic University of Marche, Ancona, Italy https://orcid.org/0000-0003-1887-5377

Contact: f.mei@staff.univpm.it
Special interests: Pleural disease, Non-specific pleuritis, Thoracic Ultrasound, Thoracoscopy

Steven Walker

Pulmonologist. PhD Academic respiratory unit, University of Bristol, Bristol, UK https://orcid.org/0000-0002-1713-5484

Contact: steven.walker@bristol.ac.uk Special interests: Pneumothorax, interventional trials.

Jane Alexandra Shaw

Pulmonologist, Clinician scientist Immunology Research Group, Biomedical Research Institute, and Division of Pulmonology, Department of Medicine, Stellenbosch University, Cape Town, South Africa https://orcid.org/0000-0002-9893-3073

Contact: janeshaw@sun.ac.za
Special interests: Tuberculosis, Ultrasound guided pleural interventions, biomarkers

IMPACT International Scientific Advisory Board

IMPACT is supported by the international scientific advisory committee, composed of some of the
most preeminent researchers and clinicians in the growing field of pleural disease. These individuals
provide strategic input on new projects and analyses, guiding the CRC in performing research which
is scientifically relevant and has meaningful impact on patients.

Rahul Bhatnagar

Academic Respiratory Unit, University of Bristol, Bristol, UK

Respiratory Department, Southmead Hospital, North Bristol NHS Trust, Bristol, UK

Kevin Blyth

Queen Elizabeth University Hospital, Glasgow, UK

Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK

Marios Froudarakis

Department of Pulmonology and Thoracic Oncology, North Hospital, University Hospital of Saint‐Etienne, Saint‐Priest‐en‐Jarez France

Coenie Koegelenberg

Division of Pulmonology, Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa

Christian B Laursen

Odense Respiratory Research Unit (ODIN), Institute of Clinical Research, University of Southern Denmark, Odense, Denmark

Department of Respiratory Medicine, Odense University Hospital, Odense, Denmark

Fabien Maldonado

Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

YC Gary Lee

Respiratory Department, Sir Charles Gairdner Hospital, Perth Western Australia, Australia

School of Medicine, University of Western Australia, Perth Western Australia, Australia

Nick Maskell

Academic Respiratory Unit, University of Bristol, Bristol, UK

Respiratory Department, Southmead Hospital, North Bristol NHS Trust, Bristol, UK

Mohammed Munavvar

Respiratory Department, Lancashire Teaching Hospitals NHS Trust, Preston, UK

University of Central Lancashire, Preston, UK

Jose Porcel

Pleural Medicine Unit, Department of Internal Medicine, Arnau de Vilanova University Hospital, IRBLleida, University of Lleida, Lleida, Spain

Najib Rahman

Oxford Centre for Respiratory Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK

Oxford NIHR Biomedical Research Centre, Oxford, UK

Specific aims

The vision of the IMPACT is to provide an international platform for pleural disease research that has global clinical impact which is relevant to patients. With this purpose, IMPACT aims specifically to:

  • to build an international network of researchers and experts in pleural disease to guide future research and clinical priorities to improve the life of people living with pleural disease globally;
  • to establish the research priorities of patients suffering from pleural disease, to create a patient-centred approach to future pleural medicine research;
  • to attract new researchers and clinicians to the field of pleural disease;
  • to support and encourage early career researchers through involvement in network
    activities, and provide fellowship opportunities through network-funded projects;

IMPACT administrator

Jenny Symonds

IMPACT is supported by an experienced research project administrator: Jenny Symonds, 

Department of Respiratory Medicine, Southmead Hospital, Bristol, UK

Contact: Jenny.Symonds@nbt.nhs.uk


If you are interested in more information about the CRC IMPACT or would like to join the network,
please contact jenny.symonds@nbt.nhs.uk