The long-anticipated update to the 2010 BTS Pleural Disease Guidelines was published in July 2023. With new evidence-based decision-making algorithms for spontaneous pneumothorax, malignant effusions, pleural infection, and investigation of unilateral pleural effusions, each recommendation is accompanied by a systematic review and metanalysis (where possible). For the full guideline and supplementary appendices see the BTS website: https://www.brit-thoracic.org.uk/quality-improvement/guidelines/pleural-disease/